Prenatal Stress Enhances Responsiveness to Cocaine
نویسندگان
چکیده
منابع مشابه
VTA BDNF enhances social stress-induced compulsive cocaine bingeing
Every day in the United States, 120 people die as a result of drug overdose, a rate that has more than doubled from 1999 to 2013 [1]. The degree of vulnerability to addiction is determined by the interaction between genetic and environmental factors. Social stress is an environmental factor some experience on a daily basis (e.g., domestic abuse, bullying, work-related issues, etc.). Since peopl...
متن کامل[Prenatal exposure to cocaine: review of the neurobehavioral effects]
OBJECTIVE: To study prenatal cocaine exposure, emphasizing its behavioral effects. METHODS: Literature review of the last 15 years, through Medline and direct search. RESULTS AND CONCLUSIONS: According to the literature, the incidence of prenatal cocaine exposure is up to 15.5%, and its effects on the newborn are particularly on the development of the nervous system. Pediatricians and sub-speci...
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Several agents may treat cocaine addiction and toxicity including bromocriptine, desipramine, GBR 12909 [1-(2-(bis(4-fluorphenyl)-methoxy)-ethyl)-4-(3-phenyl-propyl) piperazine], diazepam, buprenorphine and dizocilpine. In this study, we sought to determine whether these specific therapeutic agents alter cardiovascular responses to cocaine in conscious rats. Arterial pressure responses to cocai...
متن کاملPrenatal Cocaine Disrupts Serotonin Signaling-Dependent Behaviors: Implications for Sex Differences, Early Stress and Prenatal SSRI Exposure
Prenatal cocaine (PC) exposure negatively impacts the developing nervous system, including numerous changes in serotonergic signaling. Cocaine, a competitive antagonist of the serotonin transporter, similar to selective serotonin reuptake inhibitors (SSRIs), also blocks dopamine and norepinephrine transporters, leaving the direct mechanism through which cocaine disrupts the developing serotonin...
متن کاملThird pathophysiology of prenatal cocaine exposure.
The pathophysiology of the effects of cocaine on fetal development has been described along 2 major pathways: neurochemical effects and vasoconstrictive effects. Following a summary of these effects, we suggest a 'third pathophysiology' in which altered fetal programming affects the acute and long-term adverse effects of in utero cocaine exposure. We describe how cocaine as a stressor alters th...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2007
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1301447